Aminoglycoside antibiotics including gentamicin, bekanamycin, tobramycin, lincomycin, neomycin, kanamycin, and ribostamycin have been determined by CE‐EC with copper clectrodes. Both copper wall‐jet electrodes (WJEs) and copper on‐capillary electrodes (OCEs) were evaluated. The OCEs provided μM detection limits, superior stability and reproducibility (2–3% relative standard deviation in oxidation current), and a simple instrumental set‐up without the need for capillary/electrode alignment. The analytical capabilities of the Cu‐OCE were examined, following the optimization of CE conditions, for the seven aminoglycosides above; and the practical utility of this approach was demonstrated through the determination of aminoglycoside antibiotics in three pharmaceutical preparations.
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Voegel et al. (1997) studied this question.
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