August 6, 2018Biology of Blood and Marrow TransplantationOpen Access

Initial High Viral Load Is Associated with Prolonged Shedding of Human Rhinovirus in Allogeneic Hematopoietic Cell Transplant Recipients

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Why the study?

Is initial high viral load associated with prolonged shedding of human rhinovirus in allogeneic hematopoietic cell transplant recipients?

Structured PICO

Is initial high viral load associated with prolonged shedding of human rhinovirus in allogeneic hematopoietic cell transplant recipients?

Population

38 allogeneic hematopoietic cell transplant (HCT) recipients with symptomatic human rhinovirus (HRV) infection and a negative test within 2 weeks of the last positive (32 adults, 6 children).

Intervention

Initial high viral load (low cycle threshold [Ct] value)

Comparator

Initial low viral load (high Ct value)

Outcome

Prolonged shedding of HRV (≥21 days)surrogate

In allogeneic HCT recipients, an initial high viral load is associated with prolonged shedding of human rhinovirus.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May help risk-stratify infection control measures in allogeneic transplant recipients; leaves open whether cycle.

Cite This Study

Ogimi et al. (2018) studied this question.

synapsesocial.com/papers/6a8d2c6f2fb87b53917fe9c7 https://doi.org/10.1016/j.bbmt.2018.07.006

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Initial High Viral Load Is Associated with Prolonged Shedding of Human Rhinovirus in Allogeneic Hematopoietic Cell Transplant Recipients

Structured PICO

Discussion

Implication

Cite This Study

Initial High Viral Load Is Associated with Prolonged Shedding of Human Rhinovirus in Allogeneic Hematopoietic Cell Transplant Recipients

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider