were widely used for mild hypertension in the 1960s and '70s might have done more harm than good,44 and this mistake may be potentially repeated in subjects with hypercholesterolaemia. Doubts are even stronger in women: firstly, the effect of cholesterol lowering remains to be shown and, secondly, the incidence of coronary heart disease is already very low in middle aged women.
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Sandeman et al. (1991) studied this question.
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