LOOKING at disease abstractedly, I should say that no indications exceed in importance the two follow- ing, viZ.: 1.The alleviation of acute pain, whether neu- ralgic, spasmodic, or inflammatory, in its origin; and 2. The securing adequate daily rest in sleep by procuring, artificially if necessary, a suspension at least of any morbid actions or conditions that might militate against refreshing repose.Almost all the suffering, and great part of the danger, of sickness may be referred to uneasy sensations of one sort or other, the irritated nervous tissues re-acting throughout the economy on the nutrient functions,
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John Clendinning (1843) studied this question.