The E,Z ‐configured 1,3‐diene unit is a common motif in numerous bioactive natural products. Although several powerful methods are available to produce these motifs with high levels of selectivity, their construction within a complex, polyfunctionalised structure, such as a natural product, requires well‐defined strategies to avoid undesirable reactions and low‐to‐moderate selectivities. The aim of this review is to provide a full account of the stereoselective strategies for building E,Z ‐configured 1,3‐dienes, as well as to highlight selected total syntheses that employ them. magnified image
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Hubert et al. (2020) studied this question.
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