Sporadic appearance of a nuclear artifact had hampered accurate microscopic evaluation of lymph node and bone marrow biopsies. Although troubleshooting included specimen handling, fixation and staining, all changes in methodology failed to produce consistently good quality sections. Improved morphologic detail was attained only after blocks were recut and sections were completely dried before heat-affixation. Complete drying of sections before heat-affixation was the only factor that consistently prevented the artifact. (The J Histotechnol 13:135, 1990).
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Santoianni et al. (1990) studied this question.
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