A new pentacyclic triterpenoid from the leaves of Rhododendron dauricum L. with inhibition of NO production in LPS-induced RAW 264.7 cells

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Jiaming Wanga, Mei Jinb, Chunshi Jina, Chao Yea, Yi Zhoua, Rongshen Wanga, Huanhuan Cuia, Wei Zhoua* & Gao Lia*a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules Ministry of Education, Yanbian University College of Pharmacy, Yanji, P. R. China; b Department of Pharmacy, Yanbian University Hospital, Yanji, P. R. China* Jiaming Wang and Mei Jin contributed equally to the work.Supplemental data for this article can be accessed at https://doi.org/10.1080/14786419.2019.1566822CONTACT Gao Li gli@ybu.edu.cn; Wei Zhou zhouwei8452@163.comAbstractA new pentacyclic triterpenoid, 3-oxo-urs-11,13(18)-dien-28-oic acid (1), along with twelve known triterpenoids, α-amyrin (2), 19α-hydroxy-α-amyrin (3), triptohypol E (4), uvaol (5), 2α,3α-dihydroxyurs-11-en-13β,28-olide (6), 3β-hydroxyurs-11-en-13β,28-olide (7), ursolic acid (8), asiatic acid (9), oleanolic acid (10), aegiceradienol (11), obtusalin (12) and betulinic acid (13) were isolated from the leaves of Rhododendron dauricum L. Their structures were established from spectroscopic data and comparison with reported values. Among them, compounds 3, 4, 6, 7 and 11 were isolated from the Ericaceae family for the first time. Compounds 2, 5, 9, 12 and 13 were obtained from R. dauricum for the first time. Additionally, compounds 6, 10 and 11 significantly inhibited the levels of NO in LPS-stimulated RAW 264.7 cells at 3 μM.