A new type of safety-catch linker cleaved by intramolecular activation of an amide anchorage and allowing aqueous processing in solid-phase peptide synthesis

The N3-phenyloxycarbonyl-L-2,3-diaminopropionic acid residue behaves as a versatile iinker [Dpr(Phoc)linker] displaying high stability under neutral and acidic conditions but undergoes activation under mild alkaline conditions for the release of peptide acids or amides by nucleophilic cleavage.