Immune‐Enriched Versus Matrix‐Remodeling Microenvironments in Psammoma Body‐Rich and Psammoma Body‐Poor WHO Grade I Meningiomas: An Exploratory Transcriptomic Study
Transcriptomic study reveals immune pathway enrichment in psammoma body-rich grade I meningiomas, indicating that chronic inflammation drives tumor calcification.
Key Points
To investigate whether psammoma body-rich and psammoma body-poor WHO grade I meningiomas exhibit distinct transcriptional programs and to clarify the molecular environment underlying tumor calcification.
Analyzed the public gene expression dataset GSE43290 comprising 8 psammoma body-rich and 24 psammoma body-poor WHO grade I meningiomas.
Conducted differential expression analysis via GEO2R and functional pathway enrichment analysis using g:Profiler.
Psammoma body-rich tumors exhibited marked upregulation of immune and inflammatory cascades, including chemokine signaling, leukocyte activation, NF-κB, and Toll-like receptor pathways.
Psammoma body-rich tumors correlated with NK-cell and cytotoxic T-cell signatures, whereas psammoma body-poor tumors were predominantly enriched in extracellular matrix remodeling, collagen organization, and elastic fiber assembly.