Recent advances in microchannel plate technology and their application to image intensification have made real-time, quantum-limited imaging a practical reality for applications in optical microscopy. Detectors employing both optical and electrical outputs allow systems to be configured for video rate or real-time data acquisition. Properly implemented in conjunction with digital image processing systems, these detectors are capable of accurately imaging single photons and, through temporal accumulation, producing quantitative, high-quality images over an exceptionally wide dynamic range.
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Robert A. Wick (1987) studied this question.
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