Key result
Historically, glyceryl trinitrate had no equal in the treatment of angina pectoris, remaining mostly unchallenged well into the professional lives of many practicing cardiologists.
A historical reflection on the early literature regarding the medical treatment of angina pectoris, highlighting the enduring role of glyceryl trinitrate.
Recalls glyceryl trinitrate's historical primacy in angina; leaves open its comparative role amid modern therapies.
From the Royal Sussex County Hospital, Brighton Fifty years ago, the treatment of angina pectoris made no strong claim for space in journals of cardiology. In January 1939 Maurice Campbell submit- ted the first article on angina to be published in the British Heart Journal,' but it was no more than a case report. Five years were to pass before a paper on treatment appeared, written by Wilfred Stokes.2 He reported an investigation of the value of nicotinic acid in this condition but concluded that the drug did not improve either the prevention or relief of pain. The first and last sentences of the article were similar: both stated that glyceryl trinitrate had no equal in the treatment of angina pectoris-a con- tention that remained true and mostly unchallenged well into the professional lives of many cardiologists practising today.
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D. A. Chamberlain (1987) conducted an editorial in angina pectoris. glyceryl trinitrate was evaluated. Historically, glyceryl trinitrate had no equal in the treatment of angina pectoris, remaining mostly unchallenged well into the professional lives of many practicing cardiologists.
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