Key result
Washington University polyomavirus (WUPyV) was detected in 7.5% of pediatric patients with acute respiratory tract infections, of which 72.1% were coinfected with other viruses.
Why the study?
What is the molecular epidemiology and prevalence of WUPyV in hospitalized children with acute respiratory tract infections in China?
Observational (n=1,617)
What is the molecular epidemiology and prevalence of WUPyV in hospitalized children with acute respiratory tract infections in China?
WUPyV is persistently circulating in China among children with acute respiratory tract infections, with a high rate of viral coinfection and emergence of new phylogenetic clusters.
AIM: To explore the molecular epidemiology and clinical characteristics of Washington University polyomavirus (WUPyV) infection in pediatric patients with acute respiratory tract infections in China. MATERIALS & METHODS: A laboratory surveillance was performed to recruit pediatric patients with acute respiratory tract infections. WUPyV was detected using real-time PCR and complete genome was sequenced for randomly selected positive nasopharyngeal aspirate. RESULTS: Altogether 122 (7.5%) of 1617 children found to be infected with WUPyV and 88 (72.1%) were coinfected with other viruses during 2012-2015. The phylogenetic analysis showed that 14 strains from our study formed two new clusters (Id and IIIc) within the Branch I and Branch III, respectively. CONCLUSION: WUPyV is persistently circulating in China. Surveillance on WUPyV infection in wider areas and long persistence is warranted.
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Zhu et al. (2017) conducted an observational in acute respiratory tract infections (n=1,617). Washington University polyomavirus (WUPyV) infection was evaluated on WUPyV infection prevalence. Washington University polyomavirus (WUPyV) was detected in 7.5% of pediatric patients with acute respiratory tract infections, of which 72.1% were coinfected with other viruses.
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