Key result
In vivo and in vitro binding analyses revealed that LIMK1 self-associates through an interaction between its N-terminal LIM domain and C-terminal kinase domain.
Authors
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Does not support clinical practice changes; leaves open LIMK1 self-association as a research target in cardiovascular models.
Hiraoka et al. (1996) studied this question. Variously deleted mutants of LIMK1 was evaluated on Protein-protein interaction and self-association. In vivo and in vitro binding analyses revealed that LIMK1 self-associates through an interaction between its N-terminal LIM domain and C-terminal kinase domain.
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