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January 1, 1969Cardiovascular Research

The Negative Inotropic Effect of Adrenergic Beta-receptor Blocking Drugs on Human Heart Muscle

WG Nayler Denise Chipperfield T. E. Lowe

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Abstract

Dose-response curves obtained for the negative inotropic effect of three β-adrenergic receptor blocking compounds on human heart muscle closely resemble those obtained when dog heart muscle is used; the negative inotropic effect of Ciba 39,089-Ba on human heart muscle is significantly less than that of propranolol. The depressant effect of propranolol was not abolished by reserpine-pretreatment.

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Nayler et al. (1969) studied this question.

synapsesocial.com/papers/6a8db53b6193ac906088ddc7 https://doi.org/10.1093/cvr/3.1.30

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