Oxidative Amidation of Methylarenes and Heteroamines under Metal‐Free Conditions

Synthesis of heteroamides through oxidative amidation of methylarenes with hetero aromatic amines using tert ‐Butyl hydroperoxide (TBHP) as oxidant has been described. The present method represents a significant development for the oxidative amidation of methylarenes to obtain heteroamides which does not require metal catalyst and TBHP act as only oxidant. Methylarenes are easy to handle, stable, commercially available (by‐products in gasoline industry) and used as carbonyl source for amide synthesis. The reaction proceeds through the imine intermediate formation and its subsequent oxidation by TBHP provides the desired amides.