Key result
Therapeutic approaches to stimulate coronary arteriogenesis, including cytokines, growth factors, and mechanical stimulation, are reviewed for their potential clinical application in coronary artery disease.
This review provides an overview of current therapeutic approaches and trials aimed at stimulating coronary collateral circulation in patients with coronary artery disease.
Arteriogenesis as a way to restore blood flow after arterial occlusion has been under investigation for the treatment of coronary artery disease (CAD) for decades. Therapeutic approaches so far have included delivery of cytokines and growth factors as well as mechanical stimulation such as external counterpulsation. As knowledge on the mechanisms of arteriogenesis expanded, new therapeutic approaches have emerged. This review summarizes recent attempts to stimulate the growth of the coronary vasculature and discusses their potential in clinical application. This article also delivers an overview of current studies and trials on coronary arteriogenesis.
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Degen et al. (2014) conducted a review in Coronary artery disease (CAD). Stimulation of the coronary collateral circulation (cytokines, growth factors, mechanical stimulation) was evaluated. Therapeutic approaches to stimulate coronary arteriogenesis, including cytokines, growth factors, and mechanical stimulation, are reviewed for their potential clinical application in coronary artery disease.
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