Key result
Chemical sympathectomy with 6-OHDA selectively reduced noradrenaline without a parallel decrease in dopamine in the mesenteric and renal arteries, suggesting a noradrenaline-independent dopamine pool.
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Suggests independent vascular dopamine storage; leaves open its physiological role and relevance to human disease.
Caramona et al. (1985) studied this question. 6-hydroxydopamine (6-OHDA) alone or with pargyline vs. Control animals was evaluated on Dopamine, noradrenaline, and adrenaline depletion in peripheral tissues. Chemical sympathectomy with 6-OHDA selectively reduced noradrenaline without a parallel decrease in dopamine in the mesenteric and renal arteries, suggesting a noradrenaline-independent dopamine pool.
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