TETANUS is an extremely serious disease, whose mortality rate remains extremely high in spite of the institution of heroic measures for combating the intoxication and controlling the convulsive seizures that it produces. Treatment of this infection necessitates the careful control of at least five factors if a successful outcome is to be expected. Often, even with the most rigid adherence to these principles, failure results.Of the greatest importance is the rapid and effective neutralization of absorbed tetanus toxin. If this has already been fixed to nervous tissue, it apparently cannot be inactivated by antitoxin, regardless of how large a . . .
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Weinstein et al. (1945) studied this question.