Triple coronary thrombosis: autopsy case and literature review

Triple coronary artery thrombosis is a rare cause of acute myocardial infarction, and is associated with high mortality. Only a few cases of simultaneous multiple-vessel coronary thrombosis have been reported in the medical literature. This paper reports a unique case of sudden cardiac death in 36-year-old man without relevant risk factors who suffered from acute myocardial infarction due to simultaneous triple coronary artery thrombosis. Autopsy and histopathology examinations revealed near-total thrombotic occlusion in all three main coronary arteries. While the exact mechanism behind the simultaneous formation of these thrombi remains unclear, this paper discusses certain risk factors that may contribute to multiple coronary thrombosis. A review of previously reported cases of coronary thrombosis involving all three major coronary arteries in the literature is also provided to contribute to the understanding of this rare and potentially fatal condition. Obtaining a detailed medical and family history, collecting and saving blood samples for potential genetic analyses, and testing for Novel Coronavirus disease could be beneficial in cases of multiple coronary artery thrombosis to detect a potential underlying cause and provide prevention to family members at risk.