Comparative neuroimaging study demonstrates altered fronto-striatal dynamic connectivity in Parkinson's disease, indicating that temporal network dynamics shape dopaminergic motor treatment response.
Background Differences in dopaminergic motor response in Parkinson’s disease (PD) patients are related to specific PD subtypes. An important factor driving dopaminergic response might lie in the temporal dynamics in corticostriatal connections. Objectives The aim of this study is to determine if altered resting-state dynamic functional network connectivity (dFNC) is associated with dopaminergic motor response. Methods We assessed static and dFNC in 32 PD patients and 18 healthy controls (HC). Patients were subgrouped according to their dopaminergic motor response as low and high responders using a median split. Results Patients featuring high dopaminergic responses spent more time in a regionally more integrated state 1 compared to HC. Furthermore, dFNC between aMCC/dACC (anterior midcingulate cortex/dorsal anterior cingulate cortex) and putamen was lower in low responders during a more segregated state 2 and correlated with dopaminergic motor response. Conclusions Alterations in temporal dynamics of fronto-striatal connectivity might underlie treatment response in PD.
No takes yet. Share an insight, caveat, or question.
Hensel et al. (2022) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: