Key result
Primary dedifferentiated liposarcoma of the transverse colon is an exceptionally rare and aggressive tumor, with three of the five reported cases resulting in death within 3 years of surgery.
Why the study?
Dedifferentiated liposarcoma is an aggressive subtype of liposarcoma that rarely arises within the abdominal cavity.
Case Report (n=5)
Dedifferentiated liposarcoma of the transverse colon is extremely rare but appears to be associated with poor outcomes and high mortality.
Highlights dedifferentiated liposarcoma as a rare differential for extraluminal colon masses; leaves open the.
Dedifferentiated liposarcoma (DDL) is an aggressive subtype of liposarcoma that rarely arises within the abdominal cavity. We describe the case of a 71-year-old female incidental transverse colon mass suspicious for colorectal cancer. Pre-operative biopsy at colonoscopy was not possible due to the lesion's extraluminal location; however, complete resection was achieved through left hemicolectomy. Histology confirmed DDL. Review of the literature found four additional cases of DDL in the transverse colon. Clinical presentation, management, and follow-up were reviewed, illustrating poor outcomes; three of the five cases died within 3 years of surgery. DDL is associated with higher rates of local recurrence, metastasis, and mortality compared to well-differentiated liposarcomas. While limited by its rarity, DDL in the transverse colon appears to follow similarly poor outcomes.
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Hawkins et al. (2025) conducted a case report in Dedifferentiated liposarcoma of transverse colon (n=5). Surgical resection was evaluated. Primary dedifferentiated liposarcoma of the transverse colon is an exceptionally rare and aggressive tumor, with three of the five reported cases resulting in death within 3 years of surgery.
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