One of the most challenging tasks for formulators in the pharmaceutical industry is the formulation of poorly soluble drugs. Conventional techniques employed for improving solubility of these drugs have gained limited success. This holds true more often when dealing with drugs having poor aqueous as well as organic solubility. Nanoparticles facilitates formulation of hydrophobic drugs to improve solubility and efficacy mainly through nanosuspension approach. Nanosuspensions are submicron colloidal dispersions of pure drug particles, stabilized by surfactants. This nanobiomedicine delivery system is simple and advantageous compared to other strategies. Techniques such as media milling, high-pressure homogenization, and use of microemulsion as a template have been used for production of nanosuspensions. This green nanobiomedicine can be delivered by various routes, such as oral, parenteral, pulmonary, and ocular systems. It is also possible to convert nanosuspensions to patient-acceptable dosage fo...
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R. Ravichandran (2009) studied this question.