The blood irradiation dose for complete treatment of the disease was estimated from the nomogram in 802 patients previously treated with 1311.The mean dose was 16.6 rads, but in some patients receiving multiple treatments it was much greater, ranging up to 160 rads.The bone-marrow dose is estimated as 80% of the blood dose.Consideration of these results suggests that the risk of leukaemogenesis is slight and does not contraindicate 1311 therapy of thyrotoxicosis.Nevertheless it is important to record all cases of leukaemia occurring after 1311 therapy so that the validity of these conclusions may be examined.We acknowledge with appreciation the helpful comments of Dr.
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W.B. Matthews (1961) studied this question.
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