Why the study?
Do local anaesthetics (lidocaine, bupivacaine, tocainide) inhibit platelet aggregation in platelet-rich plasma?
Population
Platelet-rich plasma stimulated by physiological doses of adenosine-diphosphate and collagen
Design
Preclinical
Authors
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Should not yet change practice; hypothesis-generating for thromboembolism reduction with epidural anaesthesia.
Do local anaesthetics (lidocaine, bupivacaine, tocainide) inhibit platelet aggregation in platelet-rich plasma?
Local anaesthetics, particularly lidocaine, demonstrate time-dependent anti-platelet aggregation effects in vitro, which may explain the reduced thromboembolism risk observed with epidural anaesthesia.
Borg et al. (1985) studied this question.