About 90% of the soluble amyloid β (sAβ) that circulates in normal human plasma is associated with lipoprotein particles. In sporadic Alzheimer's disease patients, free sAβ42 but not sAβ40 is increased approximately 2.3-fold compared with age-matched controls, although a more marked elevation (approximately 8-fold for free sAβ40 and about 20-fold for sAβ42) is found in Down's syndrome patients. The data suggest that lipoprotein-sAβ dissociation may contribute to the influx of sAβ into the brain as a result of decreased plasma clearance. Ann Neurol 1999;45:537–541
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Matsubara et al. (1999) studied this question.
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