Key result
Poor cognitive function was associated with an increased risk of mortality compared with high scorers (RR 1.7 for 1st-10th percentile; RR 1.3 for 11th-25th percentile).
Cohort (n=2,123)
Relative Risk: 1.7
May aid mortality risk stratification; leaves open whether cognitive interventions alter survival.
Baseline neuropsychological function was assessed in 2,123 Framingham Heart Study participants and was related to mortality over an 8- to 10-year follow-up period. During that time, 573 persons died. Using Cox proportional hazards models, the authors showed poor cognitive function to be consistently associated with an increased risk of death. This association persisted after adjustment for the confounding effects of age, education, and illness. Subjects scoring below the 26th percentile of performance were at increased risk of mortality compared with high scorers (the relative risk was 1.3 for the 11th percentile-25th percentile and 1.7 for the 1st percentile-10th percentile).
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Liu et al. (1991) reported a cohort. Poor cognitive function vs. High scorers was evaluated on Mortality (RR 1.7). Poor cognitive function was associated with an increased risk of mortality compared with high scorers (RR 1.7 for 1st-10th percentile; RR 1.3 for 11th-25th percentile).
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