Key result
Saffold cardiovirus infection showed no evidence of association with multiple sclerosis, with specific oligoclonal bands found in 8.3% of MS patients and 7.4% of controls.
Why the study?
Is Saffold cardiovirus infection associated with multiple sclerosis?
Case-Control (n=79)
Is Saffold cardiovirus infection associated with multiple sclerosis?
There is no evidence to support an association between Saffold cardiovirus infection and multiple sclerosis.
Saffold cardiovirus, a newly discovered human cardiovirus, has close similarity with Theiler's murine encephalomyelitis virus (TMEV) which can cause a chronic demyelinating encephalomyelitis in mice. In this study, we tested whether Saffold cardiovirus infection of the brain is associated with multiple sclerosis (MS). Autopsy white matter samples from 19 MS and 9 normal brain donors were tested by polymerase chain reaction. All were negative. Paired cerebrospinal fluid and serum samples from 24 MS patients and 27 controls were tested for Saffold cardiovirus-specific oligoclonal bands, two patients and two controls reacted positive. We conclude that an association between Saffold cardiovirus and MS is highly improbable.
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Galama et al. (2014) conducted a case-control in Multiple sclerosis (n=79). Saffold cardiovirus vs. Controls without multiple sclerosis was evaluated on Saffold cardiovirus-specific oligoclonal bands in paired cerebrospinal fluid and serum. Saffold cardiovirus infection showed no evidence of association with multiple sclerosis, with specific oligoclonal bands found in 8.3% of MS patients and 7.4% of controls.
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