Key result
The highest quartile of neutrophil to lymphocyte ratio (OR 2.037) and stress hyperglycemia ratio (OR 1.733) were independently associated with an increased risk of new-onset atrial fibrillation in patients with acute myocardial infarction.
Why the study?
New-onset atrial fibrillation post-acute myocardial infarction is associated with worse outcomes, prompting assessment of stress hyperglycemia ratio and neutrophil to lymphocyte ratio to predict NOAF in AMI.
Do high stress hyperglycemia ratio and neutrophil to lymphocyte ratio predict new-onset atrial fibrillation in patients with acute myocardial infarction?
Cohort (n=3,194)
No
Do high stress hyperglycemia ratio and neutrophil to lymphocyte ratio predict new-onset atrial fibrillation in patients with acute myocardial infarction?
Answers are grounded in this paper and cite their sources.
High stress hyperglycemia ratio and neutrophil to lymphocyte ratio are independent predictors of new-onset atrial fibrillation during hospitalization for acute myocardial infarction, and can be combined in a nomogram for risk stratification.
Background: The occurrence of new-onset atrial fibrillation (NOAF) post-acute myocardial infarction (AMI) is associated with worse outcomes. In this study, we sought to assess the predictive effect of stress hyperglycemia ratio (SHR) and neutrophil to lymphocyte ratio (NLR) to predict NOAF in patients with AMI. Materials and methods: We recruited 3,194 individuals with AMI but free of atrial fibrillation (AF). AMI cases were stratified into groups according to SHR and NLR quartiles and were further categorized based on diabetes status. High SHR and high NLR were defined as the highest quartile of SHR and NLR. A nomogram incorporating risk factors for NOAF was constructed using multivariate logistic regression analyses. The performance of the novel nomogram was tested for predictive performance, agreement between the actual and predicted probability, and clinical utility using area under the curve (AUC), bootstrapped calibration curves, and decision curve analysis, respectively. Result: A total of 245 (7.67%) patients developed NOAF post-AMI. The NOAF cases had higher values of SHR and NLR than non-NOAF patients after AMI regardless of diabetes status. After adjusting for potential confounders, high SHR and NLR were independently associated with NOAF post-AMI. Moreover, the novel nomogram incorporating high NLR and high SHR for NOAF risk estimation in patients with AMI showed satisfactory performance assessed by the AUC, calibration curves, decision curve analysis. Conclusion: SHR and NLR were independently associated with NOAF in AMI patients. The constructed novel nomogram that incorporates SHR and NLR might assist in NOAF risk stratification post-AMI.
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Pan et al. (2022) conducted a cohort in Acute myocardial infarction (n=3,194). High neutrophil to lymphocyte ratio (highest quartile) vs. Lowest quartile of neutrophil to lymphocyte ratio was evaluated on New-onset atrial fibrillation (NOAF) post-AMI (OR 2.037, 95% CI 1.341-3.095, p=0.001). The highest quartile of neutrophil to lymphocyte ratio (OR 2.037) and stress hyperglycemia ratio (OR 1.733) were independently associated with an increased risk of new-onset atrial fibrillation in patients with acute myocardial infarction.
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