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THE purpose of this communication is to evaluate the clinical use of ACTH in nonspecific ulcerative colitis and regional enteritis. The immediate and long-term effects of this treatment on the clinical course of 6 patients with ulcerative colitis and 2 patients with regional enteritis have been studied over a period of sixteen months, and the response to ACTH therapy was correlated with the fecal lysozyme titer, which is a measure of the activity of the disease.The rationale of this use of ACTH is based upon its beneficial effect on systemic diseases involving mesenchymal tissue or in which an antigen–antibody . . .
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Gray et al. (1951) studied this question.
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