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We report on the preparation and drug delivery application of shell sheddable micelles based on disulfide-linked star-shaped copolymer of poly(ε-caprolactone) and poly(ethyl glycol) (6sPCL-SS-PEG). Interestingly, the micelles exhibit high stability normally and rapid destabilization under a reduction environment, eliciting GSH dependent cytotoxicity of drug-loaded formulations on tumor cells.
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Ren et al. (2011) studied this question.
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