Childhood Exposures and Risk of Malignancy in Adulthood

Pediatricians have significant roles in preventive health care, and understanding how various exposures during childhood can have long-lasting effects on cancer risk is critical in promoting future health. With the exception of rare genetic syndromes conferring increased cancer susceptibility, most cancers are considered idiopathic and may be influenced by modifiable exposures and risks. This review aims to serve as a brief overview of a subset of known exposures during childhood that have been associated with an increased risk of malignancy in adulthood, including the effects of radiation, chemotherapy, pesticides, nutrition, puberty, and infection.