The bichromophoric pigment bilirubin acts as a molecular exciton in its UV−visible and circular dichroism (CD) spectroscopy. The optically active analogue, (β R,β‘ R )-dimethylmesobilirubin-XIIIα exhibits intense bisignate CD Cotton effects in the region of its long wavelength UV−vis absorption near 400 nm, with Δ +337, Δ −186 in the nonpolar solvent CHCl 3, and nearly as intense Cotton effects in the polar, hydrogen bonding solvent CH 3 OH: Δ +285, Δ −177. Addition of amines leads to Cotton effect sign inversions: in isopropylamine Δ −605, Δ +375, due to an inversion of molecular chirality.
No takes yet. Share an insight, caveat, or question.
Boiadjiev et al. (1999) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: