A Weighted Gene Co-expression Network Analysis Reveals lncRNA Abnormalities in the Peripheral Blood Associated With Ultra-High-Risk for Psychosis

Figures

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  Figure 1. Zsummary statistics for the preservation of lncRNA modules. Most lncRNA network modules from individuals at ultra-high risk (UHR) for psychosis or typically developing controls(TDCs) are well-preserved. Zsummary is the summary statistics of module preservation. The vertical axis represents the Zsummary score, and the horizontal axis represents the LncRNA numbers in each module. Zsummary < 2.0 implies no evidence for preservation.

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  Figure 2. LncRNA co-expression network modules. The lncRNAs were organized into twelve co-expression network modules. Different colors represent different modules, and gray represents lncRNAs that cannot be merged into any module.

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  Figure 3. Correlation between lncRNAs module eigengenes (ME) disease characteristics. Each row corresponds to a module eigengene, each column to a trait. Each cell contains the corresponding correlation and the P-value. The table is color-coded by the correlation according to the color legend. Group represents the disease trait of individuals at ultra-high risk (UHR) for psychosis or typically developing controls.

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  Figure 4. Hub lncRNAs in brown and yellow modules related to UHR. Hub lncRNAs in the module were identified according to the absolute values of GS (gene significance) and kME (eigengene connectivity) of each lncRNA. The depth of point represents the absolute value of GS, and the depth of line represents the absolute value of kME.

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  Figure 5. Zsummary statistics for the preservation of mRNA modules. Most mRNA network modules from individuals at ultra-high risk (UHR) for psychosis or typically developing controls(TDCs) are well-preserved. Zsummary is the summary statistics of module preservation. The vertical axis represents the Zsummary score, and the horizontal axis represents the LncRNA numbers in each module. Zsummary < 2.0 implies no evidence for preservation.

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  Figure 6. mRNA co-expression network modules. The mRNAs were organized into eleven co-expression network modules. Different colors represent different modules, and gray represents lncRNAs that cannot be merged into any module.

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  Figure 7. Correlation between mRNAs module eigengenes (ME) disease characteristics. Each row corresponds to a module eigengene, each column to a trait. Each cell contains the corresponding correlation and the P-value. The table is color-coded by the correlation according to the color legend. Group represents the disease trait of individuals at ultra-high risk (UHR) for psychosis or typically developing controls.

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  Figure 8. Hub mRNAs in red and pink modules related to UHR. Hub mRNAs in the module were identified according to the absolute values of GS (gene significance) and kME (eigengene connectivity) of each lncRNA. The depth of point represents the absolute value of GS, and the depth of line represents the absolute value of kME.