Key result
Induced hypotension using hexamethonium bromide during 407 orthopaedic operations was evaluated for blood loss and safety, with two deaths from circulatory failure reported.
Why the study?
Does induced hypotension with hexamethonium bromide affect blood loss and safety in orthopaedic surgery?
Observational (n=407)
Does induced hypotension with hexamethonium bromide affect blood loss and safety in orthopaedic surgery?
Induced hypotension with hexamethonium bromide in orthopaedic surgery carries significant risks, including circulatory failure and reactionary haemorrhage.
Highlights risks of circulatory failure with hexamethonium bromide; leaves open safer modern alternatives for blood-loss reduction in orthopaedics.
Figures relating to blood loss and post-anaesthetic progress during and after 407 orthopaedic operations performed with the aid of hexamethonium bromide are presented. 2. Two deaths from circulatory failure are examined in detail. 3. The criteria that must be observed to ensure safety are discussed. 4. Measures designed to avoid reactionary haemorrhage are enumerated. 5. Observations regarding contra-indications are presented.
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F. Holmes (1956) conducted an observational in Orthopaedic surgery (n=407). Hexamethonium bromide (induced hypotension) was evaluated on Blood loss and post-anaesthetic progress. Induced hypotension using hexamethonium bromide during 407 orthopaedic operations was evaluated for blood loss and safety, with two deaths from circulatory failure reported.
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