Lipoyl dehydrogenase (NADH:lipoamide oxidoreductase, EC 1.6.4.3), highly purified from pig brain, is similar in physical and kinetic properties to the enzyme from other mammalian sources. Lipoyl dehydrogenase is markedly inhibited by pteridines, but its transhydrogenase and diaphorase activities are unaffected. Mitochondrial keto acid oxidation is also inhibited by pteridines, although the inhibition is only significant at 10-3 m pteridine.
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Millard et al. (1969) studied this question.
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