Key result
Oral glucose administration elicits a greater and more prolonged insulin response compared to intravenous glucose, whereas peripheral and portal vein injections yield similar insulin secretion.
Why the study?
Do gastrointestinal hormones affect insulin and glucagon secretion?
Do gastrointestinal hormones affect insulin and glucagon secretion?
The text introduces the concept that oral glucose stimulates greater insulin secretion than intravenous glucose, pointing to the role of gastrointestinal hormones.
May implicate gut hormones in postprandial insulin secretion; leaves open specific mediators and therapeutic relevance.
IT has been well established that the insulin response to orally administered glucose is greater than that to glucose given intravenously.1 After oral glucose, serum insulin not only rises to higher absolute levels but also remains elevated for a longer time than after intravenous glucose.2 Oral glucose administration accelerates the disappearance of a subsequent intravenous glucose load.3 Increased insulin secretion has been also observed after an oral glucose load in subjects with end-to-side portacaval shunts.4 However, insulin secretion is similar after injection of glucose into a peripheral vein and into the portal vein during transumbilical portal-vein catheterization,5 showing that portal . . .
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Creutzfeldt et al. (1970) reported a review. Oral glucose vs. Intravenous glucose was evaluated. Oral glucose administration elicits a greater and more prolonged insulin response compared to intravenous glucose, whereas peripheral and portal vein injections yield similar insulin secretion.
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