Key result
Endovascular stenting for severe coarctation of the aorta effectively reduced the mean pressure gradient from 71.7 mmHg pre-procedure to 3.6 mmHg post-procedure.
Why the study?
Does endovascular stenting reduce pressure gradients in patients with severe coarctation of the aorta?
Observational (n=22)
No
Does endovascular stenting reduce pressure gradients in patients with severe coarctation of the aorta?
Absolute Event Rate: 3.6% vs 71.7%
Endovascular stenting for severe coarctation of the aorta provides immediate and near-complete relief of obstruction, though long-term follow-up is needed for persistent hypertension and restenosis.
Stenting was associated with immediate gradient relief in coarctation; leaves open long-term hypertension and restenosis outcomes.
Background: Endovascular stenting is the preferred option in managing coarctation of aorta (COA) in older children and adults. Covered stents are used in selected or high risk category of patients. We present our experience with stenting of coarctation of aorta. Materials and Methods: Patients with severe coarctation of aorta who underwent endovascular stenting during the period July 2013 to July 2016 were retrospectively analysed. CT aortogram was used for pre procedural imaging. Procedural outcome complications and short term follow up were noted. Results: 22 patients (seven females) aged 1-52 years (median 29), weighing 7.8 -86.4 (median 55.1) kg, underwent stenting of COA. All except one had post subclavian coarctation. 68.2% of patients had hypertension and were on treatment. Mean gradient at catheterisation was 71.7 28.6 mm hg and mean gradient post procedure was 3.6 4.4 mmhg. A total of 22 stents were deployed, Covered CP (12), Cook Formula (1), Advanta V12 Atrium (2), Intrastent Mega(3), Palmaz (2), Andrastent.(1),Bare CP (1). Covered stents were used in 59.1%.The mean stent length was 35 12.5 mm. Pre dilatation was done in two patients including one with near interruption. Post dilatation was needed in 36.4% of patients. Procedural complications included retroperitoneal hemorrhage in one which resulted in mortality. Follow-up ranged from 1 month to 3.5 years. 36.4% required continuation of antihypertensive therapy even after stenting. One patient with presubclavian coarctation required redilatation 6 months after stenting. Conclusions: Stent implantation is a safe and effective alternative to surgical repair in COA. It provides immediate and near complete relief of obstruction which is sustained on short term follow up. Long term follow up is required to look for restenosis, aneurysm formation and persistent systemic hypertension.
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Dr Lakshmi Sadasivan Pillai (2017) conducted an observational in Coarctation of aorta (n=22). Endovascular stenting was evaluated on Mean pressure gradient at catheterisation. Endovascular stenting for severe coarctation of the aorta effectively reduced the mean pressure gradient from 71.7 mmHg pre-procedure to 3.6 mmHg post-procedure.
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