Key result
3D echocardiography demonstrated excellent volumetric agreement with true human cadaveric left atrial cast volumes, with an absolute bias of -0.7 ml (95% CI -6.1 to 4.6) using GE 4D LVQ software.
Why the study?
Left atrial volume is a prognostic factor in cardiac pathologies, and the authors aimed to validate left atrial volume measurement by 3DE and 2DE against human cadaveric casts.
Does 3D echocardiography accurately measure left atrial volume compared to true volumes in human cadaveric casts?
Comparison
3DE volumetry vs 2DE vs true cast volumes
Design
In vitro validation study
Authors
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3DE accuracy in vitro supports further validation studies; does not yet warrant changes in clinical LA volumetry.
Does 3D echocardiography accurately measure left atrial volume compared to true volumes in human cadaveric casts?
Mean Difference: -0.7 (95% CI -6.1–4.6)
Absolute Event Rate: -0.7% vs 2.9%
3D echocardiography provides highly accurate and repeatable measurements of left atrial volume in vitro, outperforming 2D echocardiography by avoiding volume-dependent bias.
Kuusisto et al. (2018) studied Left atrial volume measurement (n=13). 3D echocardiography vs. True volume (water displacement) and 2D echocardiography was evaluated on Volumetric agreement (bias) between measured and true cast volumes (bias -0.7 ml, 95% CI -6.1 to 4.6). 3D echocardiography demonstrated excellent volumetric agreement with true human cadaveric left atrial cast volumes, with an absolute bias of -0.7 ml (95% CI -6.1 to 4.6) using GE 4D LVQ software.
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