Key result
Functional human skeletal muscle Cl- channels (hClC-1) consist of two subunits, as demonstrated by the gating properties of heterodimeric channels expressed in a mammalian cell line.
Demonstrates that the functional human skeletal muscle chloride channel (hClC-1) is a dimer.
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May refine models of muscle channelopathies; leaves open translation from cell-line data to human physiology.
Fahlke et al. (1997) studied this question. Dimeric human skeletal muscle Cl- channels with D136G mutation vs. Homodimeric WT-WT and D136G-D136G constructs was evaluated on Subunit stoichiometry and channel gating properties. Functional human skeletal muscle Cl- channels (hClC-1) consist of two subunits, as demonstrated by the gating properties of heterodimeric channels expressed in a mammalian cell line.
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