Key result
A high-fat meal or injection of large molecular solutions in hamsters caused reversible increased adhesiveness and aggregation of red blood cells, platelet clumping, and slowed circulation.
Why the study?
Does a high-fat meal or injection of large molecular solutions cause intravascular aggregation and adhesiveness of blood elements in hamsters?
Population
Hamsters (intact circulation model)
Comparison
Meal high in fat content or injection of large… vs Normal state
Design
Preclinical
Authors
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May inform mechanisms of postprandial thrombosis; leaves open translation from hamster model to humans.
Does a high-fat meal or injection of large molecular solutions cause intravascular aggregation and adhesiveness of blood elements in hamsters?
Alimentary lipemia and large molecular solutions induce reversible intravascular aggregation of blood elements and slowing of circulation in a hamster model, potentially relating to vascular thrombosis.
CULLEN et al. (1954) studied this question. Meal high in fat content and injections of large molecular solutions was evaluated on Intravascular aggregation and adhesiveness of red blood cells, platelet clumping, and slowing of circulation. A high-fat meal or injection of large molecular solutions in hamsters caused reversible increased adhesiveness and aggregation of red blood cells, platelet clumping, and slowed circulation.
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