Key result
Diabetic patients with autonomic neuropathy had markedly reduced maximal gastric acid output (3.49 mEq/hr) compared to diabetic patients without autonomic neuropathy (9.59 mEq/hr) and healthy controls (15.99 mEq/hr).
Cross-Sectional (n=37)
No
Absolute Event Rate: 3.49% vs 9.59%
Diabetic patients with autonomic neuropathy exhibit significantly reduced gastric acid secretion and fundic gland area, with hypergastrinemia likely reflecting a negative feedback mechanism.
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Diabetic autonomic neuropathy is associated with reduced gastric acid output; cross-sectional data leave open causal mechanisms and clinical relevance.
Nakamura et al. (1994) conducted a cross-sectional in Diabetes mellitus with autonomic neuropathy (n=37). Diabetic autonomic neuropathy vs. Diabetic patients without autonomic neuropathy and healthy controls was evaluated on Maximal acid output (MAO) in mEq/hr. Diabetic patients with autonomic neuropathy had markedly reduced maximal gastric acid output (3.49 mEq/hr) compared to diabetic patients without autonomic neuropathy (9.59 mEq/hr) and healthy controls (15.99 mEq/hr).
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