A dangerous matchmaker: In the presence of HgII ions, DNA polymerases incorporated thymidine 5′-triphosphate (TTP) at the site opposite thymine in a template strand and made a phosphodiester bond to elongate the primer strand. This unusual metal-mediated base pair was recognized by the DNA polymerases, which went on to synthesize the full-length product (see picture).
No takes yet. Share an insight, caveat, or question.
Urata et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: