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November 10, 2005Journal of VirologyOpen Access

Herpes Simplex Virus 1 Immediate-Early and Early Gene Expression during Reactivation from Latency under Conditions That Prevent Infectious Virus Production

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Population

Latently infected murine ganglia

Comparison

Acyclovir or WAY-150138 vs Untreated ganglia

Design

Preclinical

Follow-up

48 hours postexplant

Authors

JPJean M. PesolaJZJia ZhuDKDavid M. Knipe

Discussion

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Overview

High late expression reflects secondary spread, not initial reactivation; leaves open relevance to in vivo HSV dynamics.

Structured PICO

P
Population
Latently infected murine ganglia
I
Intervention
Acyclovir (inhibits viral DNA synthesis) or WAY-150138 (inhibits viral DNA encapsidation)
C
Comparator
Untreated ganglia
O
Outcome
Amounts of viral RNA, DNA, or infectious virus (specifically five immediate-early and early RNAs)surrogate

High levels of viral gene expression at 48 h postexplant are largely due to the production of infectious virus and subsequent spread through the tissue, rather than initial reactivation events.

Cite This Study

Pesola et al. (2005) studied this question.

synapsesocial.com/papers/6a8fb6510f86a7a1ffcedb56https://doi.org/10.1128/jvi.79.23.14516-14525.2005
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