An ethanol extract of the powdered twigs of Podocarpus imbricatus afforded 14 new diterpenoids ( 1 – 14 ), which all share an aromatized C ring. These isolates belong to five diterpenoid types that include abietanes ( 1 – 3 ), semperviranes ( 4 – 9 ), totaranes ( 10 – 12 ), a C-17 norabietane ( 13 ), and an icetexane ( 14 ). Their structures were assigned mainly by analysis of the spectroscopic data, and the absolute configuration of 1 was determined by X-ray crystallography. A biosynthetic pathway for five of the biogenetically related types of diterpenoids was proposed. Compound 7 showed moderate inhibitory activity against Zika virus with an IC 50 value of 2.5 μM.
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