Carcinogenicity of TCDD in Laboratory Animals: Implications for Risk Assessment

Keywords CDD, chlorinated dibenzo-p-furans, CDIF, chlorinated dibenzofurans, DEN, diethylnitrosamine, ED50, dose which produces 50% of the maximum effect, EGF, epidermal growth factor, EGFR, epidermal growth factor receptor, EOF, enzyme altered foci, ER, estrogen receptor, HCDD, hexachlorodibenzo-p-dioxin, Kd, dissociation constant, LOEL, lowest observed effect level, MFO, mixed function oxidase, MNNG, N-methyl N'-Nitro, N-Nitrosoguanidine, MTD, maximum tolerated dose, NOEL, no observed effect level, OVX rats, ovariectomized rats, PAH, polycyclic aromatic hydrocarbons, PCB, polychlorinated biphenyls, PCDF, pentachlorodibenzofuran, PGT, placental glutathione transferase, TCDD, 2,3,7,8-tetrachloradibenzo-p-dioxin, TGF-α, transforming growth factor-α, TSH, thyroid stimulating hormone, UDPGT, uridine diphosphoglucuronly transferase