Central alpha-2-adrenoceptor function was studied in seven withdrawing alcoholics and compared with seven normal controls using the clonidine challenge test. The alcoholic group had significantly elevated basal levels of blood pressure and plasma 3-methoxy-4-hydroxy-phenyl glycol. The percentage of fall in blood pressure produced by clonidine was blunted in the alcoholics. There was disruption of the neuroendocrine effects of clonidine on growth hormone release. Physiological indices of withdrawal, in particular plasma 3-methoxy-4-hydroxyphenyl glycol and blood pressure correlated with measures of previous withdrawal experiences, supporting the idea that kindling might occur with repeated episodes of withdrawal.
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Nutt et al. (1988) studied this question.
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