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January 1, 2009Journal of Postgraduate MedicineOpen Access

Aspirin resistance in Indian patients with coronary artery disease and cardiovascular events

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Why the study?

Do elevated urinary 11-dehydrothromboxane B2 levels predict recurrent cardiovascular events in Indian patients with stable coronary artery disease on chronic aspirin therapy?

Population

84 Indian participants.

Comparison

Measurement of urinary 11-Dehydrothromboxane B2… vs Lower two quartiles of urinary…

Design

Cohort, Non randomized

Follow-up

median 36 months

Authors

VTVS ThomsonBJBobby JohnPGPaul V. George

Discussion

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Overview

May flag higher recurrent risk on aspirin in stable CAD; hypothesis-generating and requires prospective validation before testing informs care.

Structured PICO

Do elevated urinary 11-dehydrothromboxane B2 levels predict recurrent cardiovascular events in Indian patients with stable coronary artery disease on chronic aspirin therapy?

P
Population
84 Indian participants (63 patients with stable documented coronary artery disease on chronic aspirin therapy and 21 healthy volunteers).
I
Intervention
Measurement of urinary 11-Dehydrothromboxane B2 levels as a surrogate marker for aspirin resistance
C
Comparator
Lower two quartiles of urinary 11-dehydrothromboxane B2 levels
O
Outcome
Composite of acute coronary syndrome, stroke, revascularization and death at median 36 months follow-upcomposite

Elevated urinary 11-dehydrothromboxane B2 levels, indicating aspirin resistance, are associated with a higher risk of recurrent vascular events in Indian patients with stable coronary artery disease.

Cite This Study

Thomson et al. (2009) studied this question.

synapsesocial.com/papers/6a8fde5a41f68ebe5041434fhttps://doi.org/10.4103/0022-3859.58927
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