Preparation, Properties and Cell Biocompatibility of Room Temperature LCST-Hydrogels Based on Thermoresponsive PEO Stars

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A series of star and linear polymers based on a poly(ethylene oxide) core and poly(diethylene glycol ethyl ether acrylate) outer arms were synthesised by atom-transfer radical polymerization. The polydispersity of the polymers were low, showing good control of initiation and growth. They all showed lower critical solution (LCST) behaviour, and at 30% concentration most gelled at or below room temperature. The behaviour depended on the number and length of the arms, with the polymers with longer arms gelling at a lower temperature and producing stiffer gels. The shear modulus of the gels varied between 1 and 48 kPa, with the gelling temperature varying between 16 and 23 °C. Attempted cell cultures with the polymers proved unsuccessful, which was determined to be due to the high concentration of polymers needed for gelling.