Experimental study demonstrates high cold-chain stability and temperature-induced degradation of bioresorbable emulsions, highlighting viable processing parameters for scalable vaccine adjuvants.
Among adjuvants for licensed human vaccines, oil-in-water emulsions are tasked with helping the person to induce quick and potent vaccine adaptive immune responses against emerging infectious diseases. This study investigates how operating parameters—pressure, cycle number, and oil content—affect droplet size characteristics in the preparation of a degradable emulsion using microfluidized process. Subsequently, stability was assessed under cold-chain storage and mimic physiological environments. Results showed that the emulsion based on amphiphilic bioresorbable copolymer exhibited high stability upon microfluidization and cold chain storage; on the other hand, the instability of the oil/water interfaces within the emulsion followed a degradation-associated disintegration mechanism at physiological temperature. This work underscores the critical role of process parameters and material selection in developing effective, safe, and scalable vaccine adjuvants.
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Ho et al. (2026) studied this question.
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