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Perspective reveals how kinesin research transformed intracellular transport biology and microscopy techniques, highlighting the power of direct molecular observation.
Few proteins have inspired as much curiosity as kinesin. Since its discovery 40 years ago, kinesin has become one of the best understood molecular machines in biology, yet it continues to reveal new questions about how cells organize and move their contents. Its study transformed not only our understanding of intracellular transport but also the way biochemical mechanisms can be investigated through microscopy. In this essay, I reflect on how I first encountered kinesin and how it taught me to watch cells and proteins directly, letting observation reveal nature's workings.
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Ronald D. Vale (2026) studied this question.
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